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Colonoscopy: the least glamorous medical procedure that could save your life

A gastroenterologist on what actually happens, start to finish, and why it is worth it.

Dr Sam WithingtonGastroenterology Speciality Registrar and Suna's Gut Health Lead

3 min read. Updated .

A colonoscopy is a camera test of the large bowel. The preparation is the hard part, there are more comfort options than most people realise, and it can remove polyps before they ever become cancer. Here is what actually happens, before, during and after.

A colonoscopy uses a long, thin, flexible camera, passed through the back passage (the rectum, for US readers), to look directly at the lining of the bowel. It lets your care team spot problems such as inflammation, polyps and cancer.

Why have a colonoscopy?

Usually your doctor will suggest a colonoscopy if you have signs or test results that might point to a problem in the lower part of your gut. These include:

  • Unexplained weight loss
  • Changes in bowel habit
  • Bleeding from the back passage
  • Test results suggesting blood in your stool, such as the FIT (faecal immunochemical test) used in UK bowel cancer screening
  • Keeping an eye on a known condition

What happens before a colonoscopy?

For a colonoscopy to succeed, the bowel needs to be mostly empty so that any changes can be seen. This involves a 'low residue' (low fibre) diet and strong laxatives known as 'bowel preparation' before the day. The preparation is not a pleasant part of the process and it can be challenging, but it is very important. Good preparation allows a more complete look and reduces the chance of anything being missed.

When you arrive, the nursing team will check you in and make sure you are well and properly prepared before things begin.

How will I stay comfortable during the test?

A colonoscopy can be uncomfortable. The bowel hangs on a sheet of connective tissue called the mesentery, and it is tension on the mesentery, as the camera moves around, that causes most of the discomfort. There are several options for staying comfortable:

  • Nothing: some people have no painkillers or sedation at all
  • Gas and air (Entonox): a mix of oxygen and nitrous oxide, breathed through a mouthpiece, that takes the edge off
  • Sedation through a vein: a strong painkiller plus something to make you relaxed and sleepy
  • Deeper sedation: reserved for particular situations in the UK rather than offered routinely, and used more often in some other countries

What happens during the test?

You usually start by lying on your side. The endoscopist applies some lubricant jelly and guides the camera in, and might ask you to change position as they move around different parts of the bowel. Often you can watch on a screen, so you see what they see. They use a mix of gas and water to gently open the bowel as they go.

Usually the goal is to travel all the way around the large intestine to the caecum, where the small and large bowel meet, and often a little further into the last part of the small intestine, called the terminal ileum. It is on the way back out that the endoscopist looks most closely at the lining, checking everything is as it should be.

What happens after?

You will be looked after while any sedation wears off. If you were sedated you will need a responsible adult to take you home and stay with you, and you should not drive, drink alcohol or sign anything legally binding for 24 hours. Feeling bloated or crampy for a few hours is common as the gas passes.

Serious problems are rare, but know where to go. Call 999 or go to A&E if you have heavy bleeding from the back passage, severe tummy pain or pain that is getting worse, chest pain, or you cannot stop being sick. Call 111, or the unit where you had the test, if you have a high temperature or feel hot and shivery, or if bleeding or pain is not settling. Some spotting and mild cramping over the first day or two is normal, and if that has not settled after two days, see your doctor.

Try not to worry if a colonoscopy has been recommended for you. It is a straightforward test and your team will take good care of you before, during and after. And it earns its keep: it can remove polyps before they ever become cancer, or catch a problem at an early stage, when it is easiest to deal with.

Sources

Written by Dr Sam Withington. Contributor: Dr Parisah Hussain, MBChB, BSc (Hons), DRCOG, MRCGP. Last updated 22 October 2026. From Digests.

Digests explains how the body works in general, everyday terms. It is not medical advice. It is not a substitute for someone who can examine you and knows your history, and we do not tell you what dose of any medicine to take.

Where we describe how something is checked or looked after, we follow UK guidance from NICE and the NHS. If you are reading this outside the UK, the same concerns are worth taking to your own doctor, though the tests and routes where you live may differ.

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